4 edition of Targeted Interference with Signal Transduction Events (Recent Results in Cancer Research) found in the catalog.
July 11, 2007
Written in English
|The Physical Object|
|Number of Pages||188|
The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling. Signal transduction refers to any process by which a cell converts one kind of signal or stimulus into another, most often involving ordered sequences of biochemical reactions inside the cell, that are carried out by enzymes and linked through second messengers resulting in a"second messenger pathway".
Keywords:Angiogenesis, apoptosis, monoclonal antibody, non-small cell lung cancer, RNA interference, signal transduction, small molecules, targeted therapy. Abstract:Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. The journal publishes timely in-depth reviews, research article and drug clinical trial studies in the field of signal transduction therapy. Thematic issues are also published to cover selected areas of signal transduction therapy. Coverage of the field includes genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and.
Signal transduction pathways allow different types of cells to respond differently to the same signal molecule. Signal transduction pathways convert a signal on a cell's surface to a specific cellular response. Signal transduction pathways amplify the effect of a signal molecule. Signal transduction 1. Cellular Signal Transduction Naidu MSc Medical Biochemistry, ch Scholar 2. Monad——responds directly. Multicellular organisms——signal through elaborate system of intercellular or intracellular communication，and consequently regulate functions of organisms. 3.
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Potential drug targets have been identified, but our ability to predict the consequences of inhibition of such components is still limited. The state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.
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Get this from a library. Targeted interference with signal transduction events. [B Groner;] -- Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs.
DNA mutations of a. Ly Q.P., Yeatman T.J. () Clinical Relevance of Targeted Interference with Src-Mediated Signal Transduction Events. In: Groner B.
(eds) Targeted Interference with Signal Transduction Events. Resent Results in Cancer Research, vol Cited by: 5. Purchase Signal Transduction - 3rd Edition. Print Book & E-Book. ISBNGroner, Targeted Interference with Signal Transduction Events,Buch, Bücher schnell und portofrei.
Author(s): Groner,B(Bernd) Title(s): Targeted interference with signal transduction events/ B. Groner, ed. Country of Publication: Germany Publisher: Berlin ; New. A notable feature of Signal Transduction and Targeted Therapy is that it is a multidisciplinary journal, covering topics including but not limited to molecular biology, cell biology, pathology.
Carmen Avendaño, J. Carlos Menéndez, in Medicinal Chemistry of Anticancer Drugs, Compounds acting as ATP mimics. Imatinib (STI, from ‘ signal transduction inhibitor ’) is an inhibitor of BCR-ABL, and the first protein kinase inhibitor to be approved for cancer treatment after a particularly rapid clinical development phase.
42 It is effective in about 90% of patients with. Signal Transduction and Targeted Therapy (ISSN (online), ISSN (print), CN /R) is a new open access journal, which aims to accomplish timely publication of the latest discoveries and progress in both basic science and clinical research related to signal transduction and targeted therapy.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular ns responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used.
Signal Transduction and Targeted Therapy encompasses signal transduction in physiological and pathological processes, as well as signaling pathway-targeted therapies, including biological agents and small molecular drugs used in the management of human diseases.
Molecularly Targeted Therapy. Molecularly targeted therapy uses an agent (or combination of agents) that acts with a high degree of specificity on a well-defined target or biologic pathway that drives the cancer phenotype, so that when the patient is treated with the agent(s), there is destruction of the cancer cells, with minimal harm to normal cells.
Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling ing with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated.
Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies.
NF-κB is a central mediator of the priming signal of NLRP3 inflammasome activation and acts by inducing the transcriptional expression of NLRP3 and Cited by: Guidance Search through our collection of resources which make up all guidance issued by COPE.
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CIP2A is overexpressed in MM and is associated with poor prognosis. First, we detected the characterization of MM cell lines. U, RPMI Cited by: 6. Signal Transduction isn't the most advanced book that I've read, but it's more advanced than most. The book jacket calls this book a "text reference" and a "valuable resource".
That is the right way to see it; I have already used it to help me understand some articles on the Internet/5(7). Information about the open-access journal Signal Transduction and Targeted Therapy in DOAJ. DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed journals.
Introduction: Multiple myeloma (MM) is a hematological malignancy characterized by infiltration of malignant plasma cells in the bone marrow (BM) .Signal Transduction. Signal transduction (also known as cell signaling) is the transmission of molecular signals from a cell's exterior to its interior.
Signals received by cells must be transmitted effectively into the cell to ensure an appropriate response.Many different mammalian cell-surface receptors are coupled to a trimeric signal-transducing G protein.
As noted earlier, ligand binding to these receptors activates their associated G protein, which then activates an effector enzyme to generate an intracellular second messenger (see Figure a).
All G protein – coupled receptors (GPCRs) contain seven membrane-spanning regions with their N Cited by: 2.